.trh-app {
  --trh-primary: #253055;
  --trh-accent: #08a6a3;
  --trh-bg: #fff;
  --trh-ink: #252b38;
  --trh-muted: #4f5868;
  --trh-line: rgba(37, 48, 85, .18);
  --trh-line: color-mix(in srgb, var(--trh-primary) 18%, transparent);
  --trh-white: #fff;
  --trh-shell: 1280px;
  width: 100vw;
  width: 100dvw;
  max-width: none;
  margin-right: calc(50% - 50vw);
  margin-left: calc(50% - 50vw);
  margin-right: calc(50% - 50dvw);
  margin-left: calc(50% - 50dvw);
  overflow-x: hidden;
  overflow-x: clip;
  color: var(--trh-ink);
  background: var(--trh-bg);
  font-family: Gellix, "Helvetica Neue", Arial, sans-serif;
  font-size: 18px;
  font-weight: 400;
  line-height: 1.5;
}

.trh-app *, .trh-app *::before, .trh-app *::after { box-sizing: border-box; }
.trh-app [hidden] { display: none !important; }
.trh-shell { width: min(var(--trh-shell), calc(100% - 96px)); margin: 0 auto; }
.trh-app button, .trh-app input, .trh-app select { font: inherit; }
.trh-app button, .trh-app a { -webkit-tap-highlight-color: transparent; }
.trh-app .screen-reader-text { position: absolute !important; width: 1px; height: 1px; padding: 0; margin: -1px; overflow: hidden; clip: rect(0,0,0,0); white-space: nowrap; border: 0; }

.trh-hero {
  position: relative;
  overflow: hidden;
  padding: clamp(62px, 6vw, 78px) 0 42px;
  color: var(--trh-white);
  background: var(--trh-primary);
}

.trh-hero::after { display: none; }

.trh-hero .trh-shell { position: relative; z-index: 1; }
.trh-eyebrow { margin: 0 0 17px; color: var(--trh-accent); font-size: 14px; font-weight: 700; letter-spacing: .2em; text-transform: uppercase; }
.trh-app .trh-hero h1 { max-width: 1170px; margin: 0; color: inherit; font-family: inherit; font-size: clamp(44px, 4vw, 56px); font-weight: 300; line-height: 1.08; letter-spacing: -.035em; text-wrap: balance; }
.trh-app .trh-hero h1 strong { font-weight: 700; }
.trh-intro { max-width: 820px; margin: 12px 0 0; color: rgba(255,255,255,.82); font-size: 20px; font-style: italic; font-weight: 425; line-height: 1.5; }
.trh-search-row { margin-top: 29px; }
.trh-search { display: flex; align-items: center; width: min(820px, 100%); min-height: 61px; padding: 0; border: 0; border-bottom: 2px solid rgba(255,255,255,.78); border-radius: 0; background: transparent; box-shadow: none; }
.trh-search:focus-within { border-bottom-color: var(--trh-accent); }
.trh-search svg { flex: 0 0 auto; width: 20px; height: 20px; margin: 0 16px 0 6px; fill: none; stroke: var(--trh-white); stroke-width: 1.7; stroke-linecap: round; opacity: .75; }
.trh-search input { width: 100%; min-width: 0; min-height: 59px; margin: 0; padding: 10px 0 12px; border: 0 !important; outline: 0 !important; color: var(--trh-white); background: transparent !important; box-shadow: none !important; font-size: 30px; font-weight: 325; }
.trh-search input::placeholder { color: rgba(255,255,255,.58); opacity: 1; }
.trh-stat { display: flex; align-items: baseline; gap: 5px; margin-top: 14px; font-size: 14px; font-weight: 700; letter-spacing: .12em; }
.trh-stat strong { font-size: inherit; font-weight: 700; }
.trh-stat span { color: rgba(255,255,255,.72); font-size: inherit; font-weight: inherit; letter-spacing: inherit; }

.trh-workspace { padding-bottom: 88px; }
.trh-tabbar { display: flex; gap: clamp(24px, 3vw, 42px); min-height: 64px; overflow-x: auto; border-bottom: 1px solid var(--trh-line); scrollbar-width: none; }
.trh-tabbar::-webkit-scrollbar { display: none; }
.trh-tab { position: relative; flex: 0 0 auto; min-height: 48px; padding: 21px 0 17px; border: 0; color: var(--trh-muted); background: transparent; cursor: pointer; font-size: 16px; font-weight: 700; letter-spacing: .05em; text-transform: uppercase; white-space: nowrap; }
.trh-tab::after { content: ""; position: absolute; right: 0; bottom: -1px; left: 0; height: 4px; background: var(--trh-accent); transform: scaleX(0); transform-origin: left; transition: transform .2s ease; }
.trh-tab.is-active { color: var(--trh-primary); }
.trh-tab.is-active::after { transform: scaleX(1); }
.trh-tab:focus-visible { outline: 2px solid var(--trh-accent); outline-offset: 4px; }

.trh-panel { padding-top: 32px; }
.trh-toolbar { display: flex; align-items: center; gap: 14px; min-height: 48px; padding-bottom: 14px; border-bottom: 1px solid var(--trh-line); }
.trh-mobile-toolbar { display: none; }
.trh-evidence-layout { display: grid; grid-template-columns: minmax(0,320px) minmax(0,1fr); gap: 40px; align-items: start; }
.trh-results-column { min-width: 0; }
.trh-filter-toggle, .trh-view-toggle button, .trh-clear { border: 1px solid var(--trh-line); color: var(--trh-primary); background: var(--trh-white); cursor: pointer; }
.trh-filter-toggle { display: inline-flex; align-items: center; gap: 8px; min-height: 44px; padding: 8px 14px; font-weight: 650; }
.trh-filter-toggle svg { width: 19px; height: 19px; fill: none; stroke: currentColor; stroke-width: 1.7; stroke-linecap: round; }
.trh-filter-toggle span { display: inline-grid; place-items: center; min-width: 22px; height: 22px; border-radius: 50%; color: var(--trh-white); background: var(--trh-accent); font-size: .76rem; }
.trh-sort-label { display: flex; align-items: center; gap: 7px; margin-left: auto; color: var(--trh-muted); font-size: 16px; font-weight: 600; }
.trh-sort-label select { min-height: 40px; padding: 7px 30px 7px 9px; border: 0; border-radius: 0; color: var(--trh-primary); background-color: transparent; font-size: 16px; font-weight: 700; }
.trh-view-toggle { display: flex; }
.trh-view-toggle button { min-height: 38px; padding: 7px 15px; font-size: 14px; font-weight: 700; letter-spacing: .05em; text-transform: uppercase; }
.trh-view-toggle button + button { border-left: 0; }
.trh-view-toggle button.is-active { color: var(--trh-white); background: var(--trh-primary); }

.trh-evidence-layout .trh-filters[hidden] { display: grid !important; }
.trh-app .trh-filters { position: sticky; top: 24px; display: grid; grid-template-columns: minmax(0,1fr); gap: 0; width: 100% !important; min-width: 320px !important; max-width: 320px !important; max-height: calc(100vh - 48px); margin: 0 !important; padding: 0 0 24px !important; overflow-y: auto; background: transparent; scrollbar-width: thin; }
.trh-app .trh-filter-heading { display: flex; align-items: center; justify-content: space-between; gap: 12px; width: 100%; min-width: 0; min-height: 39px; margin: 0; padding: 0 0 12px; border-bottom: 1px solid var(--trh-line); }
.trh-app .trh-filter-heading strong { color: var(--trh-primary); font-size: 16px; font-weight: 750; letter-spacing: .06em; text-transform: uppercase; }
.trh-app .trh-filters .trh-clear { display: inline-flex !important; align-items: center !important; width: auto !important; min-width: 0 !important; min-height: 32px !important; margin: 0 !important; padding: 0 2px !important; border: 0 !important; border-radius: 0 !important; color: var(--trh-muted) !important; background: transparent !important; box-shadow: none !important; font-size: 15px !important; font-weight: 550 !important; line-height: 1.2 !important; text-transform: none !important; }
.trh-app .trh-filter-group { width: 100%; min-width: 0; margin: 0; padding: 0; border-bottom: 1px solid var(--trh-line); }
.trh-app .trh-filter-section-button { display: flex !important; align-items: center !important; justify-content: space-between !important; width: 100% !important; min-width: 0 !important; max-width: 100% !important; min-height: 48px !important; margin: 0 !important; padding: 13px 4px 11px 0 !important; border: 0 !important; border-radius: 0 !important; color: var(--trh-primary) !important; background: transparent !important; box-shadow: none !important; cursor: pointer; font-size: 16px !important; font-weight: 750 !important; letter-spacing: .05em !important; line-height: 1.2 !important; text-align: left !important; text-transform: uppercase !important; transform: none !important; }
.trh-app .trh-filter-section-button > span { position: static !important; display: block !important; flex: 0 1 auto !important; width: auto !important; min-width: 0 !important; max-width: none !important; margin: 0 !important; padding: 0 !important; color: inherit !important; font: inherit !important; letter-spacing: inherit !important; line-height: inherit !important; text-align: left !important; text-transform: inherit !important; transform: none !important; }
.trh-app .trh-filter-section-button i { display: block !important; flex: 0 0 auto; width: 8px !important; height: 8px !important; margin: 0 3px 0 12px !important; padding: 0 !important; border: 0 !important; border-right: 1px solid currentColor !important; border-bottom: 1px solid currentColor !important; background: transparent !important; transform: rotate(45deg) translateY(-2px); transition: transform .18s ease; }
.trh-app .trh-filter-section-button[aria-expanded="false"] i { transform: rotate(-45deg); }
.trh-app .trh-filter-section-button:hover,
.trh-app .trh-filter-section-button:focus,
.trh-app .trh-filters .trh-clear:hover,
.trh-app .trh-filters .trh-clear:focus,
.trh-app .trh-show-more:hover,
.trh-app .trh-show-more:focus { color: var(--trh-accent) !important; background: transparent !important; box-shadow: none !important; }
.trh-app .trh-filter-options { display: grid !important; grid-template-columns: minmax(0,1fr) !important; gap: 10px !important; width: 100% !important; min-width: 0 !important; max-width: 100% !important; margin: 0 !important; padding: 2px 4px 7px 0 !important; }
.trh-app .trh-filter-options[hidden] { display: none !important; }
.trh-app .trh-filter-options label { position: static !important; display: flex !important; flex-flow: row nowrap !important; align-items: flex-start !important; justify-content: flex-start !important; gap: 10px !important; float: none !important; clear: both !important; width: 100% !important; min-width: 0 !important; max-width: 100% !important; min-height: 0 !important; margin: 0 !important; padding: 0 !important; color: var(--trh-ink) !important; cursor: pointer; font-size: 18px !important; font-weight: 500 !important; line-height: 1.35 !important; letter-spacing: 0 !important; text-align: left !important; text-transform: none !important; transform: none !important; }
.trh-app .trh-filter-options label[hidden] { display: none !important; }
.trh-app .trh-filter-options input[type="checkbox"] { position: static !important; display: block !important; flex: 0 0 16px !important; float: none !important; width: 16px !important; min-width: 16px !important; max-width: 16px !important; height: 16px !important; min-height: 16px !important; margin: 2px 0 0 !important; padding: 0 !important; border-radius: 2px !important; accent-color: var(--trh-primary); }
.trh-app .trh-filter-options label > span { position: static !important; display: block !important; flex: 1 1 auto !important; float: none !important; width: auto !important; min-width: 0 !important; max-width: none !important; margin: 0 !important; padding: 0 !important; color: inherit !important; font: inherit !important; letter-spacing: 0 !important; line-height: inherit !important; text-align: left !important; text-transform: none !important; word-break: normal !important; overflow-wrap: normal !important; white-space: normal !important; hyphens: none !important; transform: none !important; }
.trh-app .trh-filter-options label > small { position: static !important; display: block !important; flex: 0 0 38px !important; float: none !important; width: 38px !important; min-width: 38px !important; max-width: 38px !important; margin: 0 !important; padding: 0 !important; color: var(--trh-muted) !important; font-size: 15px !important; font-weight: 600 !important; line-height: 1.4 !important; text-align: right !important; }
.trh-app .trh-show-more { display: inline-flex !important; align-items: center !important; justify-self: start; width: auto !important; min-width: 0 !important; min-height: 26px !important; margin: 0 !important; padding: 1px 0 0 !important; border: 0 !important; border-radius: 0 !important; color: var(--trh-accent) !important; background: transparent !important; box-shadow: none !important; cursor: pointer; font-size: 15px !important; font-weight: 700 !important; line-height: 1.2 !important; text-transform: none !important; }
.trh-show-more span { display: inline-block; transition: transform .18s ease; }
.trh-show-more.is-open span { transform: rotate(90deg); }
.trh-filter-logic { margin: 12px 0 0; color: var(--trh-muted); font-size: 13px; letter-spacing: .02em; }
.trh-filter-toggle:hover, .trh-clear:hover, .trh-view-toggle button:hover { border-color: var(--trh-accent); }
.trh-results-status { margin-right: auto; color: var(--trh-muted); font-size: 16px; font-weight: 500; }
.trh-results-status strong { color: var(--trh-primary); font-weight: 750; }

.trh-group { margin-top: 0; }
.trh-group-heading { display: flex; align-items: baseline; justify-content: flex-start; gap: 6px; padding: 0 4px 10px; border-bottom: 1px solid var(--trh-line); }
.trh-app .trh-group-heading h2 { margin: 0; color: var(--trh-primary); font-family: inherit; font-size: .84rem; font-weight: 750; letter-spacing: .08em; text-transform: uppercase; }
.trh-app .trh-group-heading h2::before { content: ""; display: inline-block; width: 7px; height: 7px; margin-right: 8px; background: var(--trh-accent); }
.trh-group-heading > span { color: var(--trh-primary); font-size: .84rem; font-weight: 750; letter-spacing: .08em; text-transform: uppercase; }
.trh-group-heading > span::before { content: "·"; margin-right: 6px; }

.trh-record { position: relative; padding: 21px 8px 18px 20px; border-bottom: 1px solid var(--trh-line); }
.trh-record::before { content: ""; position: absolute; top: 14px; bottom: 14px; left: 0; width: 2px; background: var(--trh-accent); opacity: .65; }
.trh-record.is-featured { padding-right: 20px; padding-left: 20px; background: linear-gradient(90deg, color-mix(in srgb, var(--trh-accent) 7%, var(--trh-white)), transparent); }
.trh-record.is-featured::before { width: 3px; opacity: 1; }
.trh-record-meta { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 8px; color: var(--trh-muted); font-size: 14px; font-weight: 700; letter-spacing: .08em; text-transform: uppercase; }
.trh-record-meta span + span::before { content: "·"; margin-right: 10px; color: var(--trh-accent); }
.trh-app .trh-record h3 { max-width: 980px; margin: 0; color: var(--trh-primary); font-family: inherit; font-size: 24px; font-weight: 675; line-height: 1.3; }
.trh-record h3 a { color: inherit; text-decoration: none; }
.trh-record h3 a:hover { color: var(--trh-accent); text-decoration: underline; text-decoration-thickness: 1px; text-underline-offset: 4px; }
.trh-citation-line { margin: 8px 0 0; color: var(--trh-muted); font-size: 17px; font-weight: 475; }
.trh-tags { display: flex; flex-wrap: wrap; gap: 5px; margin-top: 8px; }
.trh-tags span { padding: 4px 8px; border: 1px solid var(--trh-line); color: var(--trh-primary); background: color-mix(in srgb, var(--trh-accent) 4%, var(--trh-white)); font-size: 14px; font-weight: 600; }
.trh-facts { display: flex; flex-wrap: wrap; gap: 12px 28px; margin: 17px 0 0; }
.trh-facts div { display: flex; gap: 7px; }
.trh-facts dt { color: var(--trh-muted); font-size: 16px; font-weight: 600; }
.trh-facts dd { margin: 0; color: var(--trh-ink); font-size: 16px; font-weight: 700; }
.trh-summary, .trh-relevance-note { max-width: 1020px; margin-top: 16px; }
.trh-summary > strong, .trh-relevance-note > strong { color: var(--trh-primary); font-size: 15px; letter-spacing: .06em; text-transform: uppercase; }
.trh-summary p, .trh-relevance-note p { margin: 5px 0 0; color: var(--trh-ink); font-size: 18px; line-height: 1.58; }
.trh-relevance-note { padding: 12px 15px; border-left: 3px solid var(--trh-accent); background: color-mix(in srgb, var(--trh-accent) 7%, var(--trh-white)); }
.trh-actions { display: flex; flex-wrap: wrap; gap: 5px 18px; margin-top: 8px; }
.trh-actions a, .trh-actions button { display: inline-flex; align-items: center; min-height: 34px; padding: 0; border: 0; color: var(--trh-accent); background: transparent; cursor: pointer; font-size: 15px; font-weight: 700; text-decoration: none; }
.trh-actions a:hover, .trh-actions button:hover { text-decoration: underline; text-underline-offset: 3px; }

.trh-table-scroll, .trh-pipeline-scroll { max-width: 100%; overflow-x: auto; overscroll-behavior-inline: contain; -webkit-overflow-scrolling: touch; }
.trh-table-scroll { border: 1px solid var(--trh-line); background: var(--trh-white); }
.trh-table-view table { width: 100%; min-width: 1440px; margin: 0; border: 0; border-collapse: collapse; font-size: 16px; }
.trh-table-view th { padding: 13px 14px; border: 0; border-bottom: 0; color: var(--trh-primary); background: color-mix(in srgb, var(--trh-accent) 22%, var(--trh-white)); text-align: left; font-size: 14px; font-weight: 750; letter-spacing: .06em; text-transform: uppercase; white-space: nowrap; }
.trh-table-view td { padding: 14px 12px; border: 0; border-bottom: 1px solid var(--trh-line); vertical-align: top; font-weight: 400; line-height: 1.38; }
.trh-table-view td:nth-child(1) { min-width: 430px; }
.trh-table-view td:nth-child(2) { min-width: 230px; }
.trh-table-view td:nth-child(3) { min-width: 125px; }
.trh-table-view td:nth-child(4) { min-width: 235px; }
.trh-table-view td:nth-child(5) { min-width: 150px; }
.trh-table-view td:nth-child(6) { min-width: 76px; }
.trh-table-view td:nth-child(7) { min-width: 112px; white-space: nowrap; }
.trh-table-view td a { color: var(--trh-primary); text-decoration: none; }
.trh-table-view td a:hover { color: var(--trh-accent); }
.trh-table-view td small { display: block; margin-top: 5px; color: var(--trh-muted); line-height: 1.45; }
.trh-empty { margin: 36px 0; padding: 36px; border: 1px dashed var(--trh-line); text-align: center; }
.trh-app .trh-empty h3 { margin: 0; font-family: inherit; font-size: 1.5rem; font-weight: 600; }
.trh-empty p { margin: 8px 0 0; color: var(--trh-muted); }
.trh-pubmed-search { margin: 36px 0 0; text-align: right; }
.trh-pubmed-search a { display: inline-flex; align-items: center; min-height: 44px; color: var(--trh-accent); font-size: 16px; font-weight: 750; text-decoration: none; }

.trh-program-intro { display: block; width: 100%; max-width: none; padding: clamp(38px, 5vw, 68px) 0 12px; overflow: visible; }
.trh-program-intro .trh-eyebrow { margin: 0 0 20px; color: var(--trh-accent); }
.trh-app .trh-program-intro h2 { width: 100%; max-width: none; margin: 0 !important; color: var(--trh-primary); font-family: inherit; font-size: clamp(2.25rem, 4.25vw, 3.8rem); font-weight: 600; line-height: 1.08; letter-spacing: -.025em; text-wrap: balance; }
.trh-app .trh-program-intro > p:last-of-type { width: 100%; max-width: none; margin: 0 !important; padding: clamp(26px, 2.5vw, 36px) 0 0 !important; color: var(--trh-ink); font-size: clamp(1rem, 1.25vw, 1.15rem); line-height: 1.6; }
.trh-programs { display: grid; gap: 22px; margin-top: 30px; }
.trh-program-milestones { display: grid; grid-template-columns: repeat(5, minmax(0,1fr)); gap: 1px; width: 100%; margin-top: 34px; background: var(--trh-line); border: 1px solid var(--trh-line); }
.trh-program-milestones > div { min-width: 0; min-height: 150px; padding: 21px 20px; background: var(--trh-white); }
.trh-program-milestones span { display: block; color: var(--trh-accent); font-size: .76rem; font-weight: 750; letter-spacing: .12em; }
.trh-program-milestones strong { display: block; margin-top: 12px; color: var(--trh-primary); font-size: .96rem; line-height: 1.35; }
.trh-program-milestones p { margin: 15px 0 0; color: var(--trh-muted); font-size: .88rem; line-height: 1.45; }
.trh-program-card { padding: clamp(25px, 4vw, 46px); border: 1px solid var(--trh-line); background: var(--trh-white); box-shadow: 0 18px 46px color-mix(in srgb, var(--trh-primary) 7%, transparent); }
.trh-program-card.is-featured { border-top: 5px solid var(--trh-accent); }
.trh-program-status { display: flex; align-items: center; gap: 8px; color: var(--trh-primary); font-size: .82rem; font-weight: 750; letter-spacing: .08em; text-transform: uppercase; }
.trh-registry-topline { display: flex; flex-wrap: wrap; align-items: center; justify-content: space-between; gap: 12px; color: var(--trh-primary); font-size: .8rem; font-weight: 750; letter-spacing: .08em; text-transform: uppercase; }
.trh-registry-topline > span { color: var(--trh-muted); }
.trh-registry-topline > strong { display: inline-flex; align-items: center; gap: 8px; }
.trh-registry-topline i { display: inline-block; }
.trh-status-dot { width: 8px; height: 8px; border-radius: 50%; background: var(--trh-accent); box-shadow: 0 0 0 4px color-mix(in srgb, var(--trh-accent) 20%, transparent); }
.trh-app .trh-program-card h3 { max-width: 960px; margin: 16px 0 0; color: var(--trh-primary); font-family: inherit; font-size: clamp(1.55rem, 3vw, 2.35rem); font-weight: 600; line-height: 1.22; }
.trh-program-description { max-width: 980px; color: var(--trh-muted); }
.trh-program-metrics { display: grid; grid-template-columns: repeat(4, minmax(0,1fr)); gap: 1px; margin: 27px 0; background: var(--trh-line); }
.trh-program-metrics div { min-width: 0; min-height: 96px; padding: 17px; background: color-mix(in srgb, var(--trh-accent) 4%, var(--trh-white)); }
.trh-program-metrics span, .trh-program-detail > strong { display: block; color: var(--trh-muted); font-size: .78rem; font-weight: 700; letter-spacing: .06em; text-transform: uppercase; }
.trh-program-metrics strong { display: block; margin-top: 7px; overflow-wrap: anywhere; color: var(--trh-primary); font-size: 1.08rem; }
.trh-program-detail { max-width: 980px; margin-top: 18px; }
.trh-program-detail p { margin: 4px 0 0; }
.trh-program-link { margin: 24px 0 0; }
.trh-program-link a { display: inline-flex; align-items: center; min-height: 44px; color: var(--trh-accent); font-weight: 750; text-decoration: none; }
.trh-program-empty { padding: 32px; border: 1px dashed var(--trh-line); }
.trh-app .trh-program-empty h3 { margin: 0; font-family: inherit; font-weight: 600; }
.trh-program-empty p { max-width: 880px; margin: 10px 0 0; color: var(--trh-muted); }
.trh-pipeline-zone { margin-top: 18px; padding: 13px 15px; color: var(--trh-primary); background: color-mix(in srgb, var(--trh-accent) 12%, var(--trh-white)); border-left: 4px solid var(--trh-accent); font-size: .82rem; font-weight: 750; letter-spacing: .08em; text-transform: uppercase; }
.trh-pipeline-scroll { border: 1px solid var(--trh-line); border-top: 0; background: var(--trh-white); }
.trh-pipeline-table { width: 100%; min-width: 980px; margin: 0; border: 0; border-collapse: collapse; font-size: .91rem; }
.trh-pipeline-table th { padding: 14px; border: 0; border-bottom: 2px solid var(--trh-accent); color: var(--trh-primary); background: color-mix(in srgb, var(--trh-accent) 8%, var(--trh-white)); text-align: left; font-size: .76rem; letter-spacing: .06em; text-transform: uppercase; }
.trh-pipeline-table td { padding: 17px 14px; border: 0; border-bottom: 1px solid var(--trh-line); color: var(--trh-muted); vertical-align: top; }
.trh-pipeline-table tbody tr:last-child td { border-bottom: 0; }
.trh-pipeline-table .trh-pipeline-title { min-width: 220px; color: var(--trh-primary); font-weight: 750; }
.trh-program-notice { margin-top: 52px; padding: 25px 28px; border-left: 4px solid var(--trh-accent); background: color-mix(in srgb, var(--trh-accent) 7%, var(--trh-white)); }
.trh-app .trh-program-notice h2 { margin: 0; color: var(--trh-primary); font-size: .9rem; font-weight: 700; letter-spacing: .07em; text-transform: uppercase; }
.trh-program-notice p { max-width: 1120px; margin: 9px 0 0; color: var(--trh-muted); font-size: .94rem; line-height: 1.6; }

.trh-disclosure { margin-top: 62px; padding: 26px 30px; border-top: 1px solid var(--trh-line); border-bottom: 1px solid var(--trh-line); background: color-mix(in srgb, var(--trh-accent) 5%, var(--trh-white)); }
.trh-app .trh-disclosure h2 { margin: 0; color: var(--trh-primary); font-size: 16px; font-weight: 700; letter-spacing: .07em; text-transform: uppercase; }
.trh-disclosure p { max-width: 1080px; margin: 8px 0 0; color: var(--trh-muted); font-size: 17px; }
.trh-toast { position: fixed; right: 24px; bottom: 24px; z-index: 9999; max-width: 340px; padding: 12px 16px; border-radius: 2px; color: #fff; background: var(--trh-primary); box-shadow: 0 12px 36px rgba(0,0,0,.24); opacity: 0; transform: translateY(12px); pointer-events: none; transition: opacity .2s ease, transform .2s ease; }
.trh-toast.is-visible { opacity: 1; transform: translateY(0); }
.trh-app.is-program-active .trh-search-row, .trh-app.is-program-active .trh-stat, .trh-app.is-program-active .trh-disclosure { display: none; }

/* Final theme-isolation pass: keep filter rows content-sized and establish a
   readable type scale independent of the host theme's root font settings. */
.trh-app .trh-evidence-layout .trh-filters {
  display: block !important;
  height: auto !important;
  min-height: 0 !important;
}
.trh-app .trh-filter-group {
  display: block !important;
  align-self: start !important;
  height: auto !important;
  min-height: 0 !important;
  max-height: none !important;
}
.trh-app .trh-filter-options {
  position: static !important;
  display: flex !important;
  flex-flow: column nowrap !important;
  align-items: stretch !important;
  justify-content: flex-start !important;
  height: auto !important;
  min-height: 0 !important;
  max-height: none !important;
  overflow: visible !important;
  flex: none !important;
}
.trh-app .trh-filter-options[hidden] { display: none !important; }
.trh-app .trh-filter-options > * { align-self: start !important; }
.trh-app .trh-filter-options label { flex: none !important; }
.trh-app .trh-filter-options label[hidden] { display: none !important; }
.trh-app .trh-show-more {
  position: static !important;
  inset: auto !important;
  flex: none !important;
  float: none !important;
  clear: both !important;
  align-self: flex-start !important;
  grid-area: auto !important;
  transform: none !important;
}

.trh-eyebrow { font-size: 15px !important; }
.trh-app .trh-hero h1 { font-size: clamp(46px, 4vw, 58px) !important; }
.trh-intro { font-size: 21px !important; }
.trh-search input { font-size: 32px !important; }
.trh-stat { font-size: 15px !important; }
.trh-tab { font-size: 17px !important; }
.trh-sort-label, .trh-sort-label select { font-size: 18px !important; }
.trh-view-toggle button { font-size: 15px !important; }
.trh-app .trh-filter-heading strong { font-size: 17px !important; }
.trh-app .trh-filters .trh-clear { font-size: 16px !important; }
.trh-app .trh-filter-section-button { font-size: 17px !important; }
.trh-app .trh-filter-options label { font-size: 19px !important; }
.trh-app .trh-filter-options label > small { font-size: 16px !important; }
.trh-app .trh-show-more { font-size: 16px !important; }
.trh-filter-logic { font-size: 14px !important; }
.trh-results-status { font-size: 18px !important; }
.trh-record-meta { font-size: 15px !important; }
.trh-app .trh-record h3 { font-size: 26px !important; }
.trh-citation-line { font-size: 18px !important; }
.trh-tags span { font-size: 15px !important; }
.trh-facts dt, .trh-facts dd { font-size: 17px !important; }
.trh-summary > strong, .trh-relevance-note > strong { font-size: 16px !important; }
.trh-summary p, .trh-relevance-note p { font-size: 19px !important; }
.trh-actions a, .trh-actions button { font-size: 16px !important; }
.trh-table-view table { font-size: 18px !important; }
.trh-table-view th { font-size: 16px !important; }
.trh-table-view td { font-size: 18px !important; }
.trh-table-view td:first-child a { font-size: 19px !important; font-weight: 675; line-height: 1.35; }
.trh-table-view td small { font-size: 16px !important; }
.trh-app .trh-empty h3 { font-size: 26px !important; }
.trh-empty p { font-size: 18px !important; }
.trh-pubmed-search a { font-size: 18px !important; }
.trh-app .trh-disclosure h2 { font-size: 17px !important; }
.trh-disclosure p { font-size: 18px !important; line-height: 1.55; }

@media (min-width: 1120px) {
  .trh-app .trh-program-intro h2,
  .trh-app .trh-program-intro > p:last-of-type { white-space: nowrap; text-wrap: nowrap; }
}

@media (max-width: 1100px) {
  .trh-shell { width: min(var(--trh-shell), calc(100% - 56px)); }
  .trh-mobile-toolbar { display: flex; }
  .trh-evidence-layout { grid-template-columns: 1fr; gap: 16px; }
  .trh-evidence-layout .trh-filters[hidden] { display: none !important; }
  .trh-app .trh-filters { position: static; width: 100% !important; min-width: 0 !important; max-width: none !important; max-height: none; padding: 22px !important; border: 1px solid var(--trh-line); background: var(--trh-white); }
  .trh-filter-heading, .trh-filter-logic { grid-column: 1 / -1; }
  .trh-program-metrics { grid-template-columns: repeat(2, minmax(0,1fr)); }
  .trh-program-milestones { grid-template-columns: repeat(3, minmax(0,1fr)); }
}

@media (max-width: 767px) {
  .trh-app { font-size: 17px; }
  .trh-shell { width: calc(100% - 32px); }
  .trh-hero { padding: 48px 0 35px; }
  .trh-app .trh-hero h1 { font-size: clamp(38px, 9vw, 48px); }
  .trh-intro { margin-top: 12px; line-height: 1.5; }
  .trh-search-row { margin-top: 25px; }
  .trh-search { min-height: 52px; }
  .trh-search input { min-height: 50px; font-size: 25px; }
  .trh-workspace { padding-bottom: 64px; }
  .trh-tabbar { width: calc(100% + 16px); gap: 26px; min-height: 68px; }
  .trh-tab { padding-top: 22px; padding-bottom: 18px; }
  .trh-panel { padding-top: 24px; }
  .trh-toolbar { flex-wrap: wrap; }
  .trh-sort-label { order: 3; width: 100%; margin-left: 0; }
  .trh-sort-label select { flex: 1; min-width: 0; }
  .trh-view-toggle { margin-left: auto; }
  .trh-app .trh-filters { grid-template-columns: minmax(0,1fr); padding: 18px !important; }
  .trh-filter-heading, .trh-filter-logic { grid-column: auto; }
  .trh-group-heading { align-items: flex-end; gap: 12px; }
  .trh-group-heading > span { text-align: right; white-space: nowrap; }
  .trh-record { padding-top: 20px; }
  .trh-record.is-featured { padding-right: 15px; padding-left: 18px; }
  .trh-facts { display: grid; gap: 7px; }
  .trh-table-scroll, .trh-pipeline-scroll { margin-right: -16px; }
  .trh-empty { padding: 28px 20px; }
  .trh-pubmed-search { text-align: left; }
  .trh-program-intro { padding-top: 38px; }
  .trh-app .trh-program-intro h2 { font-size: clamp(2rem, 10vw, 3rem); line-height: 1.12; text-wrap: balance; }
  .trh-app .trh-program-intro > p:last-of-type { padding-top: 24px !important; }
  .trh-program-milestones { grid-template-columns: 1fr; }
  .trh-program-milestones > div { min-height: 0; padding: 18px 20px; }
  .trh-program-milestones p { margin-top: 7px; }
  .trh-program-metrics { grid-template-columns: 1fr 1fr; }
  .trh-program-card { padding: 24px 20px; }
  .trh-registry-topline { align-items: flex-start; }
  .trh-program-notice { margin-top: 42px; padding: 22px 20px; }
  .trh-disclosure { margin-top: 48px; padding: 22px 20px; }
  .trh-toast { right: 16px; bottom: 16px; left: 16px; max-width: none; }
  .trh-app .trh-hero h1 { font-size: clamp(38px, 9vw, 48px) !important; }
  .trh-intro { font-size: 18px !important; }
  .trh-search input { font-size: 25px !important; }
  .trh-results-status { font-size: 17px !important; }
  .trh-app .trh-filter-options label { font-size: 18px !important; }
  .trh-app .trh-record h3 { font-size: 23px !important; }
  .trh-citation-line { font-size: 17px !important; }
  .trh-summary p, .trh-relevance-note p { font-size: 18px !important; }
}

@media (max-width: 420px) {
  .trh-shell { width: calc(100% - 24px); }
  .trh-eyebrow { font-size: 14px !important; letter-spacing: .15em; }
  .trh-tabbar { width: calc(100% + 12px); }
  .trh-view-toggle { width: 100%; margin-left: 0; }
  .trh-view-toggle button { flex: 1; }
  .trh-program-metrics { grid-template-columns: 1fr; }
  .trh-table-scroll, .trh-pipeline-scroll { margin-right: -12px; }
}

@media (prefers-reduced-motion: reduce) {
  .trh-app *, .trh-app *::before, .trh-app *::after { scroll-behavior: auto !important; transition-duration: .01ms !important; }
}